Marla Gearing Selected Research

Detergents (Detergent)

1/2021	Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer's Disease.
12/2016	Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression.
5/2012	Quantitative analysis of the detergent-insoluble brain proteome in frontotemporal lobar degeneration using SILAC internal standards.
11/2011	Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration.
11/2009	Proteomics analysis reveals novel components in the detergent-insoluble subproteome in Alzheimer's disease.

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Marla Gearing Research Topics

Disease

46	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 03/2004
20	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 09/2004
18	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2019 - 11/2009
14	Parkinson Disease (Parkinson's Disease) 01/2021 - 02/2008
14	Frontotemporal Dementia (Semantic Dementia) 01/2021 - 09/2004
11	Cognitive Dysfunction 01/2022 - 02/2006
8	Tauopathies 01/2021 - 09/2004
7	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2019 - 02/2011
6	Cytomegalovirus Infections (Inclusion Disease) 11/2011 - 06/2004
4	Corticobasal Degeneration 11/2019 - 08/2012
4	Dementia (Dementias) 01/2019 - 02/2016
4	Inflammation (Inflammations) 01/2018 - 10/2008
4	Amyloid Plaque 11/2013 - 08/2004
3	Neuroinflammatory Diseases 10/2020 - 01/2018
3	Disease Progression 01/2019 - 12/2010
3	Neuroblastoma 01/2016 - 03/2014
3	Atrophy 12/2014 - 02/2011
3	Gliosis 11/2011 - 06/2004
3	Seizures (Absence Seizure) 05/2011 - 07/2003
2	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2016 - 08/2012
2	Sarcoma (Soft Tissue Sarcoma) 11/2011 - 02/2011
2	Hippocampal Sclerosis 05/2011 - 07/2003
2	Status Epilepticus (Complex Partial Status Epilepticus) 10/2008 - 07/2003
2	Dystonia (Limb Dystonia) 06/2006 - 10/2002
1	Stroke (Strokes) 01/2021
1	Mental Disorders (Mental Disorder) 01/2021
1	Parkinsonian Disorders (Parkinsonism) 10/2018
1	Pathologic Processes 10/2017
1	Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) 07/2014
1	Astrocytoma (Pilocytic Astrocytoma) 06/2014
1	Memory Disorders (Memory Loss) 06/2014

Drug/Important Bio-Agent (IBA)

38	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2004
11	Amyloid (Amyloid Fibrils)IBA 01/2022 - 10/2013
10	ProteomeIBA 10/2020 - 08/2004
9	Amyloid beta-PeptidesIBA 01/2021 - 02/2006
9	Biomarkers (Surrogate Marker)IBA 10/2020 - 08/2004
9	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2019 - 02/2010
8	UbiquitinIBA 10/2018 - 03/2004
6	Protein AggregatesIBA 01/2022 - 09/2004
6	RNA (Ribonucleic Acid)IBA 01/2022 - 05/2012
6	Apolipoproteins E (ApoE)IBA 01/2022 - 11/2014
6	ApolipoproteinsIBA 01/2021 - 08/2004
6	ProgranulinsIBA 10/2020 - 02/2010
5	Detergents (Detergent)IBA 01/2021 - 11/2009
4	U1 Small Nuclear RibonucleoproteinIBA 01/2018 - 10/2013
4	DNA (Deoxyribonucleic Acid)IBA 01/2018 - 12/2010
4	alpha-internexinIBA 05/2006 - 06/2004
3	Phosphotransferases (Kinase)IBA 01/2021 - 12/2010
3	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2021 - 01/2018
3	tau Proteins (tau Protein)IBA 11/2019 - 11/2012
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 08/2012 - 07/2008
3	EpitopesIBA 11/2011 - 09/2004
3	alpha-SynucleinIBA 01/2009 - 06/2004
2	Pharmaceutical PreparationsIBA 10/2020 - 10/2018
2	LipidsIBA 09/2019 - 01/2019
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019 - 03/2011
2	Dopamine (Intropin)FDA LinkGeneric 10/2018 - 07/2014
2	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 10/2017 - 02/2010
2	benzothiazoleIBA 10/2017 - 02/2010
2	sarkosylIBA 12/2016 - 12/2014
2	Small Nuclear Ribonucleoproteins (snRNP)IBA 12/2014 - 04/2014
2	EnzymesIBA 07/2014 - 05/2008
2	PesticidesIBA 03/2014 - 10/2011
2	Nuclear Proteins (Protein, Nuclear)IBA 07/2013 - 08/2012
2	Peptides (Polypeptides)IBA 05/2012 - 12/2010
2	RNA-Binding Protein FUSIBA 11/2011 - 02/2011
2	LDL Receptors (LDL Receptor)IBA 02/2011 - 08/2004
2	Pilocarpine (Ocusert)FDA LinkGeneric 10/2008 - 07/2003
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021
1	GranulinsIBA 10/2020
1	Galectin 3 (LGALS3)IBA 10/2020
1	Nerve Growth Factor (NGF)IBA 08/2019
1	CytokinesIBA 01/2019
1	HLA-DQA2 antigenIBA 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	Antihypertensive Agents (Antihypertensives)IBA 01/2019
1	Interleukin-9 (Interleukin 9)IBA 01/2019
1	Monoamine Oxidase (MAO)IBA 10/2018
1	Zonisamide (Zonegran)FDA LinkGeneric 10/2018
1	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/2018
1	NeurotoxinsIBA 10/2018
1	Biological ProductsIBA 01/2018
1	DipeptidesIBA 01/2018
1	aniline (aniline hydrobromide)IBA 10/2017
1	Complement Factor H (Factor H)IBA 02/2016
1	Complement C3 (C3 Complement)IBA 02/2016
1	Messenger RNA (mRNA)IBA 01/2016
1	rho-Associated KinasesIBA 01/2016
1	fasudil (AT 877)IBA 01/2016
1	Alanine (L-Alanine)FDA Link 02/2015
1	Threonine (L-Threonine)FDA Link 02/2015
1	Kv1.3 Potassium ChannelIBA 01/2015
1	Small Heat-Shock ProteinsIBA 01/2015
1	Small Nuclear RNA (snRNA)IBA 07/2014
1	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA 07/2014
1	purineIBA 07/2014
1	Aminobutyrates (Aminobutyric Acid)IBA 06/2014
1	gamma-Aminobutyric Acid (GABA)IBA 06/2014

Therapy/Procedure

3	Therapeutics 10/2020 - 11/2009
2	Lasers (Laser) 01/2011 - 08/2004